The Border Cats losing streak has grown to four games, despite battling back from a three-run deficit on Monday night.
William Paschal, the No. 8 hitter in the Rochester Honkers lineup, singled off Cats reliever Donnie Sellers with one out in the 10th inning, driving in Slade Heggen with the winning run.
The Honkers, who led 4-1 after three innings, edged Thunder Bay 4-3.
Carter McEachern, hitting in the lead-off position for the Cats, was 3-for-5 with three RBI.
Nate Steger, pitching his fourth inning of relief, was handed the loss. Pat Duester, who gave up one hit in the 10th, earned the victory.
The Border Cats travel to Mankato on Tuesday for the start of a two-game set and return home on Thursday to face Wisconsin.